Plasma substance P and soluble P-selectin as biomarkers of β-thalassemia induced hypercoagulability
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چکیده
منابع مشابه
Soluble E-selectin and P-Selectin Serum Levels in Patients with Psoriasis Compared to Healthy Controls
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...
متن کاملPlatelet P-Selectin Levels in Relation to Plasma Soluble P-Selectin and -Thromboglobulin Levels in Atrial Fibrillation
Background and Purpose—The increased risk of stroke and thromboembolism in atrial fibrillation (AF) may be related to a prothrombotic or hypercoagulable state, with abnormalities of hemostasis and platelet activation. To investigate the role of platelets in AF and the influence of antithrombotic therapy, we developed and then applied a new assay to detect the absolute amount of P-selectin per p...
متن کاملPlatelet P-selectin levels in relation to plasma soluble P-selectin and beta-thromboglobulin levels in atrial fibrillation.
BACKGROUND AND PURPOSE The increased risk of stroke and thromboembolism in atrial fibrillation (AF) may be related to a prothrombotic or hypercoagulable state, with abnormalities of hemostasis and platelet activation. To investigate the role of platelets in AF and the influence of antithrombotic therapy, we developed and then applied a new assay to detect the absolute amount of P-selectin per p...
متن کاملStructural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin.
P-selectin is an adhesion receptor for leukocytes on thrombin-activated platelets and endothelial cells. It contains a NH2-terminal carbohydrate-recognition domain, an epidermal growth factor motif, nine consensus repeats, a transmembrane domain, and a cytoplasmic tail. We expressed two soluble forms of P-selectin, one truncated after the ninth repeat (tPS) and the other lacking the transmembra...
متن کاملSoluble CD40 ligand and soluble P-selectin in allergic asthma patients during exercise-induced bronchoconstriction.
BACKGROUND The interactions between CD40 and its ligand, CD40L, control humoral and cell-mediated immune responses. CD40 ligation may promote asthma-associated inflammatory responses in the airways. Many reports confirm the inflammatory basis of exercise-induced bronchoconstriction (EIB) in asthmatics. METHODS The study was conducted in a group of 19 asthmatic patients (11 with EIB, 8 without...
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ژورنال
عنوان ژورنال: Alexandria Journal of Medicine
سال: 2014
ISSN: 2090-5068,2090-5076
DOI: 10.1016/j.ajme.2013.08.001